Dr. Roberto Chica
Investigating the role of naturally evolved, non-catalytic residues in enzymatic activity via computational design of miniaturized proteins
Backcountry camping, baking (and eating) granola, existentialism, language learning, and reading in hammocks.
Thornton, Ontario, Canada
Dr. Natalie Goto
Binding site characterization of the RNA-suppressor inhibitor protein p19
The area of focus for my PhD is the RNA-suppressor inhibitor protein, p19, that is found in the Carnation Italian Ringspot Virus (CIRV) and the Tomato Bushy Stunt Virus (TBSV). p19 can sequester siRNA with high binding affinity which ultimately prevents further degradation or suppression of said RNA. As p19 has been previously shown to differentiate between siRNA and miRNA through binding affinity, with certain mutations having various effects, the characteristics of p19’s binding site will be investigated using techniques such as mutagenesis, NMR, and gel-based assays.
Running, reading, being in nature with my dogs, trying new things.
Edmonton, Alberta, Canada